Gene name:
FOXO1 (FKHR;FOXO1A) ;
Protein name:
Forkhead box protein O1 ;
Alternative:
Forkhead in rhabdomyosarcoma ;Forkhead box protein O1A ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with LRPPRC (By similarity). Interacts with SIRT1 and this interaction requires the presence of KRIT1 (By similarity). Interacts with NLK (By similarity). Binds to CDK1 and 14-3-3 proteins.
Function:
Transcription factor which acts as a regulator of cell responses to oxidative stress. In the presence of KIRT1, mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence (By similarity). Triggers death of postmitotic neurons when phosphorylated by CDK1. Activates transcription of PMAIP1.
Subcellular Location:
Cytoplasm
Nucleus
Shuttles between cytoplasm and nucleus. Translocates to the nucleus upon oxidative stress induced phosphorylation at Ser-212 by STK4/MST1.
Protein Attributes:
50:
MAEAPQVVEI | DPDFEPLPRP | RSCTWPLPRP | EFSQSNSATS | SPAPSGSAAA |
100:
NPDAAAGLPS | ASAAAVSADF | MSNLSLLEES | EDFPQAPGSV | AAAVAAAAAA |
150:
AATGGLCGDF | QGPEAGCLHP | APPQPPPPGP | LSQHPPVPPA | AAGPLAGQPR |
200:
KSSSSRRNAW | GNLSYADLIT | KAIESSAEKR | LTLSQIYEWM | VKSVPYFKDK |
250:
GDSNSSAGWK | NSIRHNLSLH | SKFIRVQNEG | TGKSSWWMLN | PEGGKSGKSP |
300:
RRRAASMDNN | SKFAKSRSRA | AKKKASLQSG | QEGAGDSPGS | QFSKWPASPG |
350:
SHSNDDFDNW | STFRPRTSSN | ASTISGRLSP | IMTEQDDLGE | GDVHSMVYPP |
400:
SAAKMASTLP | SLSEISNPEN | MENLLDNLNL | LSSPTSLTVS | TQSSPGTMMQ |
450:
QTPCYSFAPP | NTSLNSPSPN | YQKYTYGQSS | MSPLPQMPIQ | TLQDNKSSYG |
500:
GMSQYNCAPG | LLKELLTSDS | PPHNDIMTPV | DPGVAQPNSR | VLGQNVMMGP |
550:
NSVMSTYGSQ | ASHNKMMNPS | SHTHPGHAQQ | TSAVNGRPLP | HTVSTMPHTS |
600:
GMNRLTQVKT | PVQVPLPHPM | QMSALGGYSS | VSSCNGYGRM | GLLHQEKLPS |
650:
DLDGMFIERL | DCDMESIIRN | DLMDGDTLDF | NFDNVLPNQS | FPHSVKTTTH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Pig
Bovine
ELISA Kit for Human Forkhead box protein O1
ELISA Kit for Human Forkhead box protein O1
ELISA Kit for Human Forkhead box protein O1
ELISA Kit for Human Forkhead box protein O1
ELISA Kit for Human Forkhead box protein O1
CLIA Kit for Human Forkhead box protein O1
CLIA Kit for Human Forkhead box protein O1
CLIA Kit for Human Forkhead box protein O1
CLIA Kit for Human Forkhead box protein O1
CLIA Kit for Human Forkhead box protein O1
Polyclonal Antibody for Human Forkhead box protein O1
Polyclonal Antibody for Human Forkhead box protein O1
Polyclonal Antibody for Human Forkhead box protein O1
Polyclonal Antibody for Human Forkhead box protein O1
Polyclonal Antibody for Human Forkhead box protein O1
Monoclonal Antibody for Human Forkhead box protein O1
Monoclonal Antibody for Human Forkhead box protein O1
Monoclonal Antibody for Human Forkhead box protein O1
Monoclonal Antibody for Human Forkhead box protein O1
Monoclonal Antibody for Human Forkhead box protein O1
Protein for Human Forkhead box protein O1
Protein for Human Forkhead box protein O1
Protein for Human Forkhead box protein O1
Protein for Human Forkhead box protein O1
Protein for Human Forkhead box protein O1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH PAX3
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue :
Rhabdomyosarcoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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more...
Nature428:522-528(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lymph .
tissue :
Placenta .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHROMOSOMAL TRANSLOCATION WITH PAX7
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-24; SER-256 AND SER-319
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DNA-BINDING;PHOSPHORYLATION AT SER-256;FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-329;MUTAGENESIS OF SER-329
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH YWHAG AND YWHAZ;PHOSPHORYLATION AT THR-24; SER-256 AND SER-319;SUBCELLULAR LOCATION;MUTAGENESIS OF THR-24; SER-256 AND SER-319
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-24; SER-256; SER-319; SER-322; SER-325 AND SER-329
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF THR-24; SER-256 AND SER-319
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CREBBP AND SIRT1;ACETYLATION;DEACETYLATION;FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EP300;ACETYLATION;SUBCELLULAR LOCATION;PHOSPHORYLATION;FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SKP2;UBIQUITINATION;MUTAGENESIS OF SER-256
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PRMT1
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT SER-249 BY CDK1;INTERACTION WITH CDK1 AND 14-3-3 PROTEINS;MUTAGENESIS OF SER-249
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-212;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF SER-212
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION AT LYS-262; LYS-265 AND LYS-274;DEACETYLATION BY SIRT2;FUNCTION IN AUTOPHAGY;INTERACTION WITH SIRT2 AND ATG7
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
23.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-212
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 151-266;DNA-BINDING;PHOSPHORYLATION AT SER-212; SER-218; SER-234 AND SER-235;ACETYLATION;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF SER-249